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研究生导师简介

博士生导师简介----林英武

发布者:  时间:2023-03-06  浏览:

 

基本信息

姓名:林英武

出生年月:1976.06

学位:博士

职称:教授

研究领域(方向):金属蛋白/金属酶结构与功能

联系方式:

邮箱:ywlin(a)usc.edu.cn; linlinying(a)hotmail.com

 

个人简介

林英武,男,安徽安庆人,bv伟德国际体育官网教授,博士生导师。日本JSPS学者、湖南省杰出青年基金获得者、湖南省121创新人才,湖南省首届优秀研究生导师。现任伟德betvlctor体育院长,蛋白质结构与功能湖南省高校重点实验室主任。相关科研成果发表于NaturePNASJACSAngew ChemCoord Chem RevACS CatalysisChem Commun、中国科学(化学)等国内外期刊累计200余篇,其中第一作者或通讯作者SCI论文100篇。20171-202012月,任国际学术期刊ChemistryOpen 期刊编委。2019年获得衡阳市青年英才奖;2020年获得徐元植顺磁共振波谱学优秀青年奖2022年获得衡阳市首届优秀科技工作者称号。20228月,入选中国化学会第四届生物物理化学专业委员会委员。2022年和2023年连续入选斯坦福大学全球前2%顶尖科学家榜单。

教育经历

2002/09-2005/12,复旦大学化学系,博士,导师:黄仲贤

1999/09-2022/06中科院上海原子核研究所,硕士,导师:尹端沚

1995/09-1999/06,安徽师范大学,化学系,本科/学士

 

科研、学术与访学工作经历

2008/07-2010/06美国伊利诺伊大学香槟分校(University of Illinois at Urbana-Champaign, UIUC)化学系从事博士后研究(导师:Prof. Yi Lu

2013/05-2013/11日本奈良先端科学技术大学(Nara Institute of Science and Technology, NAIST)从事科研合作研究(JSPS访问学者,合作者Prof. Shun Hirota

 

主持或参加科研项目(课题)情况

主持国家自然基金面上项目3项)、国家自然基金青年项目1项)、教育部留学回国启动基金、湖南省自然科学杰出青年基金、南京大学配位化学国家重点实验室开放基金等。

 

主要论文

2009-2022

1. Natasha Yeung,Ying-Wu Lin, Yi-Gui Gao, Xuan Zhao, Brandy S. Russell, Lanyu Lei, Kyle D. Miner, Howard Robinson, and Yi Lu*. Rational design of a structural and functional nitric oxide reductase. Nature, 2009, 462(7276): 1097-1082.

2. Ying-Wu Lin, Natasha Yeung, Yi-Gui Gao, Kyle D. Miner, Shiliang Tian, Howard Robinson, and Yi Lu*. Roles of glutamates and metal ions in a rationally designed nitric oxide reductase based on myoglobin.Proc Natl Acad Sci USA, 2010, 107(19): 8581-8586.

3. Ying-Wu Lin, Natasha Yeung, Yi-Gui Gao, Kyle D. Miner, Lanyu Lei, Howard Robinson, and Yi Lu*. Introducing a non-heme iron center into myoglobin confers nitric oxide reductase activity. J Am Chem Soc, 2010, 132(29): 9970-9972.

4. Ying-Wu Lin, Satoshi Nagao, Mohan Zhang, Yasuhito Shomura, Yoshiki Higuchi, Shun Hirota*. Rational Design of Heterodimeric Protein Using Domain Swapping for Myoglobin. Angew. Chem. Int. Ed. 2015, 54(2):511-5.

5. Ying-Wu Lin*. Rational design of metalloenzymes: From single to multiple active sites. Coord Chem Rev 2017, 336:1-27.(Review)IF=15.367 ESI高被引论文; Cited by Nature Reviews Chemistry, Trends in Biochemical Sciences, Current Opinion in Chemical Biology, etc)

6. Ying-Wu Lin*. Biodegradation of aromatic pollutants by metalloenzymes: A strcutural-functional-environmental perspective. Coord Chem Rev 2021,IF=22.315) 

7. Xiaojuan Wang, Chuanwan Wei*, Ji-Hu Su, Bo He, Ge-Bo Wen, Ying-Wu Lin* and Yi Zhang*. A Chiral Ligand Assembly that Confers One-electron O2 Reduction Activity for a Cu2+-selective Metallohydrogel. Angew Chem Int Ed, 2018,doi: 10.1002/anie.201801290.(IF=12.959

8. Xiao-Feng Wang*, Yangyang Chen, Li-Ping Song, Zhen Fang, Jian Zhang, Fanian Shi, Ying-Wu Lin*, Yunkai Sun, Yue-Biao Zhang*, João Rocha*.Cooperative Capture of Uranyl Ions by a Carbonyl-Bearing Hierarchical-Porous Cu-Organic Framework. Angew Chem Int Ed, 2019,58(52):18808-18812.IF=12.959)(Hot Paper

9.Lu-Lu Yin, Hong Yuan, Can Liu, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin*. A Rationally Designed Myoglobin Exhibits a Catalytic dehalogenation Efficiency More than 1000-Fold that of a Native Dehaloperoxidase. ACS Catalysis, 2018, DOI: 10.1021/acscatal.8b02979. ( IF=12.35

10. Ping Zhang, Jiakun Xu,Xiao-Juan Wang, Bo He, Shu-Qin Gao, Ying-Wu Lin*. The Third Generation of Artificial Dye-Decolorizing Peroxidase Rationally Designed in Myoglobin, ACS Catalysis2019, DOI: 10.1021/acscatal. 9b02226. (IF=12.35

11. Ping Zhang, Hong Yuan, Jiakun Xu,Xiao-Juan Wang, Shu-Qin Gao, Xianshi Tan, Ying-Wu Lin*. A Catalytic Binding Site together with a Distal Tyr in Myoglobin Affords Catalytic Efficiencies Similar to Natural Peroxidases, ACS Catalysis, 2020,10, 1, 891-896 (IF=12.35

12. Jie Luo, Ke-Jie Du, Hong Yuan, Chuan-Wan Wei, Jia-Jia Lang, Ge-Bo Wen, Yong-Hua Wang, and Ying-Wu Lin*. Rational Design of an Artificial Nuclease by Engineering a Hetero-Dinuclear Center of Mg-Heme in Myoglobin. ACS Catalysis2020,10, 24, 14359–14365 (IF=12.35

13. Lu-Lu Yin, Hong Yuan, Ke-Jie Du, Bo He, Shu-Qin Gao, Ge-Bo Wen, Xiangshi Tan and Ying-Wu Lin*. Regulation of both structure and function by a de novo designed disulfide bond: A case study of heme protein in myoglobin. Chem Commun2018, DOI: 10.1039/C8CC01646A.(IF=6.164

14. Can Liu, Hong Yuan, Fei Liao, Chuan-Wan Wei, Ke-Jie Du, Shu-Qin Gao,Xiangshi Tan and Ying-Wu Lin*.Unique Tyr-heme double cross-links in F43Y/T67R myoglobin: an artificial enzyme with a peroxidase activity comparable to that of native peroxidases. Chem Commun2019, DOI: 10.1039/C9CC02714A (IF=6.164

15. Li-Juan Sun,  Hong Yuan,  Lu Yu,  Shu-Qin Gao,  Ge-Bo Wen,  Xiangshi Tan  and  Ying-Wu Lin*. Structural and functional regulations by a disulfide bond designed in myoglobin like human neuroglobin. Chem Commun2022, 58, 5885-5888. (IF=6.164

16. Lei Chen, Hong Yuan, Xiao-Juan Wang, Lianzhi Li, Xianshi Tan, Ying-Wu Lin*. Engineering Human Neuroglobin into a Cytochrome c-like Protein with a Single Thioether Bond in Non-native State.  ChemBioChem2022, https://doi.org/10.1002/cbic.202200531

2023

17. Lang JJ, Lv Y, Kobe B, Chen H, Tan Y, Chen L, Wang X, Mi P,* Zheng X,* Lin YW.* Discovery of C-5 Pyrazole-Substituted Pyrrolopyridine Derivatives as Potent and Selective Inhibitors for Janus Kinase 1. J Med Chem, 2023, 66:6725-6742. DOI:10.1021/acs.jmedchem.3c00050 (IF=7.3

18. Li-Juan Sun,Hong Yuan,Jia-Kun Xu,Jie Luo,Jia-Jia Lang,Ge-Bo Wen,Xiangshi Tan, Ying-Wu Lin*. Phenoxazinone Synthase-like Activity of Rationally Designed Heme Enzymes Based on Myoglobin. Biochemistry 2023, https://pubs.acs.org/doi/10.1021/acs.biochem.1c00554

19. Yu Feng, Yao Dong, Ke-Jie Du*, Xi-Chun Liu, Shu-Qin Gao, Ying-Wu Lin*. The oxidative nuclease activity of human cytochrome c with mutations in Ω-loop C/D. BBA,Proteins and Proteomics. 2023,  https://doi.org/10.1016/j.bbapap.2023.140897

20. Wei Dai,  Hong Yuan,  Xiao-Juan Wang; Shu-Qin Gao,  Xiangshi Tan; Ying-Wu Lin.*  Self-oxidation of cysteine to sulfinic acid in an engineered T67C myoglobin: Structure and reactivity. RSC Chem Biol, 2023https://doi.org/10.1039/D3CB00007A

21. Binbin Yuan,  Shuangshuang Long*,  Huamin Wang; Qing Liu,  Ke Zeng, Shuqing Gao, Yingwu Lin.*  Surfactant-regulated acetylpyrene assemblies as fluorescent probes for identifying heme proteins in an aqueous solution. CCL, 2023,      ,  https://doi.org/10.1016/j.cclet.2022.107802, (IF=8.455

22. Li Yan-Yan, Long Shuang-Shuang,* Yu Lu, Liu AK, Gao Sh-Qin, Tan Xiangshi, Lin Ying-Wu*. Effects of naturally occurring S47F/A mutations on the structure and function of human cytochrome c. J Inorg Biochem, 2023, DOI: 10.1016/j.jinorgbio.2023.112296.

23. Chen YM, Liu YC, Wang JQ, Ou GC, Wang XF, Gao SQ, Du KJ,* Lin YW.* Functional copper complexes with benzofurans tridentate ligand: Synthesis, crystal structure, DNA binding and anticancer studies. J Inorg Biochem, 2023, DOI:10.1016/j.jinorgbio.2023.112330

24. Yu QY, Wei CW, Wang XJ*, Gao SQ, Tong XY, Lin YW.* A fluorescent probe based on a phenylalanine derivative is capable of sequential detection of Zn2+ and Cys/His. J Biol Inorg Chem, 2023,  8(2):205-211. DOI:10.1007/s00775-022-01984-x

25. Xin Zhang, Ling-Hua Jin, Yan-Yan Li, Zi-Zhen Xiao, Yu Feng, Ying-Wu Lin*, and Ye Zhang.* Portable self-powered photoelectrochemical immunosensor based on Cu3SnS4 nanoflower for ultra-sensitive and real-time detection of human cytochrome c. Inorg Chem Front, 2023, https://pubs.rsc.org/en/content/articlelanding/2023/qi/d3qi01234d (IF=7.0)

26.Sun LJ, Wang H, Xu JK, Gao SQ, Wen GB, Lin YW.*  Exploiting and Engineering Neuroglobin for Catalyzing Carbene N-H Insertions and the Formation of Quinoxalinones. Inorg Chem, 2023, DOI: 10.1021/acs.inorgchem.3c02855

27.Chunhui Wang, Keyi Xian, Shuangshuang Zhao, Shuailing Ma, Haozhe Qin, Dong Wang, Akhil Tayal,  Yanfei Wang, Ying-Wu Lin*, Ming Feng*, Xing Ou*. The synergy of ferric surface anchoring and interior doping engineering enables anode with boosted potassium ion storage performances. Nano Energy, 2023, 118(A): 109020. https://www.sciencedirect.com/science/article/abs/pii/S2211285523008571 (IF=17.6)

28. Guang-Rong Wu, Jia-Kun Xu*, Li-Juan Sun, Ying-Fu Li, Shu-Qin Gao, Ying-Wu Lin*. Application of engineered heme enzymes based on myoglobin with high peroxidase activity for efficient degradation of various emerging pollutants. J Environ Chem Eng, 2023,11(6): 111471 (IF=7.7) https://www.sciencedirect.com/science/article/abs/pii/S2213343723022108

29. Shuai Tang, Li-Juan Sun, Ai-Qun Pan,, Jun Huang,  Huamin Wang*, Ying-Wu Lin*. Application of Engineered Myoglobins for Biosynthesis of Clofazimine by Integration with Chemical Synthesis. Org Biomol Chem, 2023, 21(48):9603-9609. https://pubs.rsc.org/en/content/articlelanding/2023/ob/d3ob01687k/unauth

2024-

30. Wu ST,* Su HQ, Xiao QX, Qiu ZY, Huang GQ, He MN, Ge Y, Wang CH, Lin YW.* Design of bifunctional ultrathin MnO2 nanofilm with laccase-like activity for sensing environmental pollutants containing phenol groups. J Hazard Mater. 2024,461:132493.DOI: 10.1016/j.jhazmat.2023.132493 (IF=13.6)

31. Pengbing Mi,* Yan Tan, Shiying Ye , Jia-Jia Lang, You Lv, Jinhuan Jiang, Limei Chen, Jianxiong luo, Yuqing Lin, Zhonghua Yuan*, Xing Zheng*, Ying-Wu Lin*.  Discovery of C-3 isoxazole substituted thiochromone S,S-dioxide derivatives as potent and selective inhibitors for monoamine oxidase B (MAO-B). Eur J Med Chem, 2024,263: 115956 (IF=6.7) https://www.sciencedirect.com/science/article/abs/pii/S0223523423009236

32.  Ze-Yuan Chen, Hong Yuan, Huamin Wang, Li-Juan Sun, Lu Yu, Shu-Qin Gao, Xiangshi Tan, Ying-Wu Lin*.  Regulating the Heme Active Site by Covalent Modifications: Two Case Studies of Myoglobin. ChemBioChem, 2024, https://doi.org/10.1002/cbic.202300678

专利 

1. 一种脱色过氧化物酶及其制备方法与应用。ZL 2018 1 0521472.X

2. 一种脱卤过氧化物酶及其制备方法与应用。ZL 2018 1 0685384.3   

3. 一种基于金属离子-肌红蛋白突变体复合物的人工金属水解酶的制备及应用。ZL 2018 1 025184.8

4. 一种神经红蛋白突变体及其制备方法。ZL 2018 1 0795654.7

5. 一种基于肌红蛋白突变体的染料靛蓝的生物制备方法 ZL 2018 1 0708753.6

6. 一种偶氮红染料脱色酶及其制备方法与应用 ZL 2019 0 284750.9

7. 一种人工金属酶及其制备方法与应用 ZL 2020 1 0161626.6